This could turn into an Alan Moore fest but the comic that I keep trying to convince people to read but never seems to get that much acclaim is Halo Jones
The Ballad of Halo Jones started in 2000AD in 1984 and is just a revolutionary idea for a comic that at the time was full of stern lawmen, renegade robots, dinosaurs and violent resistance fighters. Into this very masculine world Moore and artist Ian Gibson introduced a female character, and a female character who had no special powers or abilities. Halo Jones was just an ordinary person who ended up doing extraordinary things because she felt trapped in her mundane life. The three books explored different chapters in her life and were just remarkable stuff for 2000AD. Underrated but recommended.